The role of dietary histone deacetylases (HDACs) inhibitors in health and disease.

ABSTRACT: Modification of the histone proteins associated with DNA is an important process in the epigenetic regulation of DNA structure and function. There are several known modifications to histones, including methylation, acetylation, and phosphorylation, and a range of factors influence each of these. Histone deacetylases (HDACs) remove the acetyl group from lysine residues within a range of proteins, including transcription factors and histones. Whilst this means that their influence on cellular processes is more complex and far-reaching than histone modifications alone, their predominant function appears to relate to histones; through deacetylation of lysine residues they can influence expression of genes encoded by DNA linked to the histone molecule. HDAC inhibitors in turn regulate the activ

SUBMITTER: Bassett SA 

PROVIDER: S-EPMC4210916 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature