Visualization of microscale particle focusing in diluted and whole blood using particle trajectory analysis.

ABSTRACT: Inertial microfluidics has demonstrated the potential to provide a rich range of capabilities to manipulate biological fluids and particles to address various challenges in biomedical science and clinical medicine. Various microchannel geometries have been used to study the inertial focusing behavior of particles suspended in simple buffer solutions or in highly diluted blood. One aspect of inertial focusing that has not been studied is how particles suspended in whole or minimally diluted blood respond to inertial forces in microchannels. The utility of imaging techniques (i.e., high-speed bright-field imaging and long exposure fluorescence (streak) imaging) primarily used to observe particle focusing in microchannels is limited in complex fluids such as whole blood due to interference fr

SUBMITTER: Lim EJ 

PROVIDER: S-EPMC4211080 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature