Lack of family-based association between common variations in WNK1 and blood pressure level.

ABSTRACT:

Background

WNK1 (With No-lysine Kinase 1) modulates numerous sodium transport-related ion channels involved in regulation of blood pressure. Several studies have indicated associations between the common variants of the WNK1 gene and hypertension or blood pressure levels. However, little data exists on Asian populations and normotensive or pre-hypertensive subjects. Our aim was to detect whether the common variations in the WNK1 gene are potential contributors to individual variations in blood pressure in a family-based sample.

Material and methods

525 individuals from 116 families were selected from a rural community of Northern China. Five single-nucleotide polymorphisms were selected from the WNK1 gene. Single-marker and haplotype analyses were conducted using the Family-

SUBMITTER: Liu F 

PROVIDER: S-EPMC4211417 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature