Interaction between genetic predisposition to adiposity and dietary protein in relation to subsequent change in body weight and waist circumference.

ABSTRACT:

Background

Genetic predisposition to adiposity may interact with dietary protein in relation to changes of anthropometry.

Objective

To investigate the interaction between genetic predisposition to higher body mass index (BMI), waist circumference (WC) or waist-hip ratio adjusted for BMI (WHRBMI) and dietary protein in relation to subsequent change in body weight (ΔBW) or change in WC (ΔWC).

Design

Three different Danish cohorts were used. In total 7,054 individuals constituted the study population with information on diet, 50 single-nucleotide polymorphisms (SNPs) associated with BMI, WC or WHRBMI, as well as potential confounders. Mean follow-up time was ∼5 years. Four genetic predisposition-scores were based on the SNPs; a complete-score including all selected adipo

SUBMITTER: Ankarfeldt MZ 

PROVIDER: S-EPMC4211714 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature