Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer's drugs: a computational investigation.

ABSTRACT: Ginger (Zingiber officinale), despite being a common dietary adjunct that contributes to the taste and flavor of foods, is well known to contain a number of potentially bioactive phytochemicals having valuable medicinal properties. Although recent studies have emphasized their benefits in Alzheimer's disease, limited information is available on the possible mechanism by which it renders anti-Alzheimer activity. Therefore, the present study seeks to employ molecular docking studies to investigate the binding interactions between active ginger components and various anti-Alzheimer drug targets. Lamarckian genetic algorithm methodology was employed for docking of 12 ligands with 13 different target proteins using AutoDock 4.2 program. Docking protocol was validated by re-docking of all native

SUBMITTER: Azam F 

PROVIDER: S-EPMC4211852 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature