FOXO1 locus and acetylcholinesterase inhibitors in elderly patients with Alzheimer's disease.

ABSTRACT:

Objective

Acetylcholinesterase inhibitors (AChEIs) may reduce the oxidative stress in brain of Alzheimer's disease (AD) patients. Forkhead box O1 (FOXO1) protein has been reported as the link between oxidative stress and AD. We evaluated a potential association between FOXO1 gene locus and the response to AChEI treatment in patients with sporadic AD.

Methods

In this prospective study, 109 Caucasian AD patients were treated with standard doses of donepezil, galantamine, or rivastigmine for 6 months. Functional and cognitive status were evaluated at baseline and after treatment. Response to therapy was defined according to the National Institute for Health and Clinical Excellence criteria. Genotype analyses, including the APOE polymorphism, were made in blinded fashion.

Res

SUBMITTER: Paroni G 

PROVIDER: S-EPMC4211854 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature