Two clinical phenotypes in polycythemia vera.

ABSTRACT:

Background

Polycythemia vera is the ultimate phenotypic consequence of the V617F mutation in Janus kinase 2 (encoded by JAK2), but the extent to which this mutation influences the behavior of the involved CD34+ hematopoietic stem cells is unknown.

Methods

We analyzed gene expression in CD34+ peripheral-blood cells from 19 patients with polycythemia vera, using oligonucleotide microarray technology after correcting for potential confounding by sex, since the phenotypic features of the disease differ between men and women.

Results

Men with polycythemia vera had twice as many up-regulated or down-regulated genes as women with polycythemia vera, in a comparison of gene expression in the patients and in healthy persons of the same sex, but there were 102 genes with differe

SUBMITTER: Spivak JL 

PROVIDER: S-EPMC4211877 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature