Development of a lauric acid/albumin hybrid iron oxide nanoparticle system with improved biocompatibility.

ABSTRACT: The promising potential of superparamagnetic iron oxide nanoparticles (SPIONs) in various nanomedical applications has been frequently reported. However, although many different synthesis methods, coatings, and functionalization techniques have been described, not many core-shell SPION drug delivery systems are available for clinicians at the moment. Here, bovine serum albumin was adsorbed onto lauric acid-stabilized SPIONs. The agglomeration behavior, zeta potential, and their dependence on the synthesis conditions were characterized with dynamic light scattering. The existence and composition of the core-shell-matrix structure was investigated by transmission electron microscopy, Fourier transform infrared spectroscopy, and zeta potential measurements. We showed that the iron oxide cores

SUBMITTER: Zaloga J 

PROVIDER: S-EPMC4211907 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature