Single-step green synthesis and characterization of gold-conjugated polyphenol nanoparticles with antioxidant and biological activities.

ABSTRACT:

Background

Gold nanoparticles (GNPs) are likely to provide an attractive platform for combining a variety of biophysicochemical properties into a unified nanodevice with great therapeutic potential. In this study we investigated the capabilities of three different natural polyphenols, epigallocatechin-3-gallate (EGCG), resveratrol (RSV), and fisetin (FS), to allow synergistic chemical reduction of gold salts to GNPs and stabilization in a single-step green process. Moreover, antioxidant properties of the nanosystems, as well as preliminary antiproliferative activity and apoptotic process investigation of model EGCG-GNPs on stable clones of neuroblastoma SH-SY5Y cells expressing CFP-DEVD-YFP reporter, were examined.

Methods

The GNPs were characterized by physicochemical techn

SUBMITTER: Sanna V 

PROVIDER: S-EPMC4211914 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature