Using biological networks to improve our understanding of infectious diseases.

ABSTRACT: Infectious diseases are the leading cause of death, particularly in developing countries. Although many drugs are available for treating the most common infectious diseases, in many cases the mechanism of action of these drugs or even their targets in the pathogen remain unknown. In addition, the key factors or processes in pathogens that facilitate infection and disease progression are often not well understood. Since proteins do not work in isolation, understanding biological systems requires a better understanding of the interconnectivity between proteins in different pathways and processes, which includes both physical and other functional interactions. Such biological networks can be generated within organisms or between organisms sharing a common environment using experimental data a

SUBMITTER: Mulder NJ 

PROVIDER: S-EPMC4212278 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature