Association of depression with accelerated cognitive decline among patients with type 2 diabetes in the ACCORD-MIND trial.

ABSTRACT:

Importance

Depression has been identified as a risk factor for dementia among patients with type 2 diabetes mellitus but the cognitive domains and patient groups most affected have not been identified.

Objective

To determine whether comorbid depression in patients with type 2 diabetes accelerates cognitive decline.

Design

A 40-month cohort study of participants in the Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) trial.

Setting

Fifty-two clinics organized into 6 clinical networks across the United States and Canada.

Participants

Two thousand nine hundred seventy-seven participants with type 2 diabetes at high risk for cardiovascular events.

Intervention

The Digit Symbol Substitution Test, Rey Auditory Verbal Le

SUBMITTER: Sullivan MD 

PROVIDER: S-EPMC4212406 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature