Prevalence of gastro-oesophageal reflux disease with upper gastrointestinal symptoms without heartburn and regurgitation.

ABSTRACT:

Background

Symptomatically 'silent' gastro-oesophageal reflux disease (GORD) may be underdiagnosed.

Objective

To determine the prevalence of untreated GORD without heartburn and/or regurgitation in primary care.

Methods

Patients were included if they had frequent upper gastrointestinal symptoms and had not taken a proton pump inhibitor in the previous 2 months (Diamond study: NCT00291746). GORD was diagnosed based on the presence of reflux oesophagitis, pathological oesophageal acid exposure, and/or a positive symptom-acid association probability. Patients completed the Reflux Disease Questionnaire (RDQ) and were interviewed by physicians using a prespecified symptom checklist.

Results

GORD was diagnosed in 197 of 336 patients investigated. Heartburn and/or reg

SUBMITTER: Vakil N 

PROVIDER: S-EPMC4212460 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature