Association of TCF7L2 variation with single islet autoantibody expression in children with type 1 diabetes.

ABSTRACT:

Background

The transcription factor 7-like 2 (TCF7L2) gene has the strongest genetic association with type 2 diabetes. TCF7L2 also associates with latent autoimmune diabetes in adults, which often presents with a single islet autoantibody, but not with classical type 1 diabetes.

Methods

We aimed to test if TCF7L2 is associated with single islet autoantibody expression in pediatric type 1 diabetes. We studied 71 prospectively recruited children who had newly diagnosed type 1 diabetes and evidence of islet autoimmunity, that is, expressed ≥1 islet autoantibody to insulin, glutamic acid decarboxylase 65, islet cell autoantigen 512, or zinc transporter 8. TCF7L2 rs7903146 alleles were identified. Data at diagnosis were cross-sectionally analyzed.

Results

We found that 21.

SUBMITTER: Redondo MJ 

PROVIDER: S-EPMC4212574 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature