Comparative Study on Sequence-Structure-Function Relationship of the Human Short-chain Dehydrogenases/Reductases Protein Family.

ABSTRACT: Human short-chain dehydrogenases/reductases (SDRs) protein family has been the subject of recent studies for its critical role in human metabolism. Studies also found that single nucleotide polymorphisms of the SDR protein family were responsible for a variety of genetic diseases, including type II diabetes. This study reports the effect of sequence variation on the structural and functional integrities of human SDR protein family using phylogenetics and correlated mutation analysis tools. Our results indicated that (i) tyrosine, serine, and lysine are signature protein residues that have direct contribution to the structural and functional stabilities of the SDR protein family, (ii) subgroups of SDR protein family have their own signature protein combination that represent their unique fu

SUBMITTER: Tang NT 

PROVIDER: S-EPMC4213187 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature