Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7.

ABSTRACT:

Background and purpose

Common variants have been identified using genome-wide association studies which contribute to intracranial aneurysms (IA) susceptibility. However, it is clear that the variants identified to date do not account for the estimated genetic contribution to disease risk.

Methods

Initial analysis was performed in a discovery sample of 2617 IA cases and 2548 controls of white ancestry. Novel chromosomal regions meeting genome-wide significance were further tested for association in 2 independent replication samples: Dutch (717 cases; 3004 controls) and Finnish (799 cases; 2317 controls). A meta-analysis was performed to combine the results from the 3 studies for key chromosomal regions of interest.

Results

Genome-wide evidence of association was detec

SUBMITTER: Foroud T 

PROVIDER: S-EPMC4213281 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature