Microbial signature profiles of periodontally healthy and diseased patients.

ABSTRACT:

Aim

To determine microbial profiles that discriminate periodontal health from different forms of periodontal diseases.

Methods

Subgingival biofilm was obtained from patients with periodontal health (27), gingivitis (11), chronic periodontitis (35) and aggressive periodontitis (24), and analysed for the presence of >250 species/phylotypes using HOMIM. Microbial differences among groups were examined by Mann-Whitney U-test. Regression analyses were performed to determine microbial risk indicators of disease.

Results

Putative and potential new periodontal pathogens were more prevalent in subjects with periodontal diseases than periodontal health. Detection of Porphyromonas endodontalis/Porphyromonas spp. (OR 9.5 [1.2-73.1]) and Tannerella forsythia (OR 38.2 [3.2-450.6]),

SUBMITTER: Lourenco TG 

PROVIDER: S-EPMC4213353 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature