Functional consequences of somatic mutations in cancer using protein pocket-based prioritization approach.

ABSTRACT:

Background

Recently, a number of large-scale cancer genome sequencing projects have generated a large volume of somatic mutations; however, identifying the functional consequences and roles of somatic mutations in tumorigenesis remains a major challenge. Researchers have identified that protein pocket regions play critical roles in the interaction of proteins with small molecules, enzymes, and nucleic acid. As such, investigating the features of somatic mutations in protein pocket regions provides a promising approach to identifying new genotype-phenotype relationships in cancer.

Methods

In this study, we developed a protein pocket-based computational approach to uncover the functional consequences of somatic mutations in cancer. We mapped 1.2 million somatic mutations acros

SUBMITTER: Vuong H 

PROVIDER: S-EPMC4213513 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature