Protein-protein docking: from interaction to interactome.

ABSTRACT: The protein-protein docking problem is one of the focal points of activity in computational biophysics and structural biology. The three-dimensional structure of a protein-protein complex, generally, is more difficult to determine experimentally than the structure of an individual protein. Adequate computational techniques to model protein interactions are important because of the growing number of known protein structures, particularly in the context of structural genomics. Docking offers tools for fundamental studies of protein interactions and provides a structural basis for drug design. Protein-protein docking is the prediction of the structure of the complex, given the structures of the individual proteins. In the heart of the docking methodology is the notion of steric and physicoche

SUBMITTER: Vakser IA 

PROVIDER: S-EPMC4213718 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature