Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis.

ABSTRACT:

Objectives

Delayed antimicrobials are associated with poor outcomes in adult sepsis, but data relating antimicrobial timing to mortality and organ dysfunction in pediatric sepsis are limited. We sought to determine the impact of antimicrobial timing on mortality and organ dysfunction in pediatric patients with severe sepsis or septic shock.

Design

Retrospective observational study.

Setting

PICU at an academic medical center.

Patients

One hundred thirty patients treated for severe sepsis or septic shock.

Interventions

None.

Measurements and main results

We determined if hourly delays from sepsis recognition to initial and first appropriate antimicrobial administration were associated with PICU mortality (primary outcome); ventilator-free, vasoactiv

SUBMITTER: Weiss SL 

PROVIDER: S-EPMC4213742 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature