Genetic Diversity of Tick-Borne Rickettsial Pathogens; Insights Gained from Distant Strains.

ABSTRACT: The ability to capture genetic variation with unprecedented resolution improves our understanding of bacterial populations and their ability to cause disease. The goal of the pathogenomics era is to define genetic diversity that results in disease. Despite the economic losses caused by vector-borne bacteria in the Order Rickettsiales, little is known about the genetic variants responsible for observed phenotypes. The tick-transmitted rickettsial pathogen Anaplasma marginale infects cattle in tropical and subtropical regions worldwide, including Australia. Genomic analysis of North American A. marginale strains reveals a closed core genome defined by high levels of Single Nucleotide Polymorphisms (SNPs). Here we report the first genome sequences and comparative analysis for Au

SUBMITTER: Pierle SA 

PROVIDER: S-EPMC4213813 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature