Beyond cigarettes per day. A genome-wide association study of the biomarker carbon monoxide.

ABSTRACT:

Rationale

The CHRNA5-CHRNA3-CHRNB4 locus is associated with self-reported smoking behavior and also harbors the strongest genetic associations with chronic obstructive pulmonary disease (COPD) and lung cancer. Because the associations with lung disease remain after adjustment for self-reported smoking behaviors, it has been asserted that CHRNA5-CHRNA3-CHRNB4 variants increase COPD and lung cancer susceptibility independently of their effects on smoking.

Objectives

To compare the genetic associations of exhaled carbon monoxide (CO), a biomarker of current cigarette exposure, with self-reported smoking behaviors.

Methods

A total of 1,521 European American and 247 African American current smokers recruited into smoking cessation studies were assessed for CO at intake bef

SUBMITTER: Bloom AJ 

PROVIDER: S-EPMC4214060 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature