Three clinically distinct chronic pediatric airway infections share a common core microbiota.

ABSTRACT:

Rationale

DNA-based microbiological studies are moving beyond studying healthy human microbiota to investigate diverse infectious diseases, including chronic respiratory infections, such as those in the airways of people with cystic fibrosis (CF) and non-CF bronchiectasis. The species identified in the respiratory secretion microbiota from such patients can be classified into those that are common and abundant among similar subjects (core) versus those that are infrequent and rare (satellite). This categorization provides a vital foundation for investigating disease pathogenesis and improving therapy. However, whether the core microbiota of people with different respiratory diseases, which are traditionally associated with specific culturable pathogens, are unique or shared with ot

SUBMITTER: van der Gast CJ 

PROVIDER: S-EPMC4214061 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature