Sex hormone pathway gene polymorphisms are associated with risk of advanced hepatitis C-related liver disease in males.

ABSTRACT:

Background

Males have excess advanced liver disease and cirrhosis risk including from chronic hepatitis C virus (HCV) infection though the reasons are unclear.

Goal

To examine the role variants in genes involved in androgen and estrogen biosynthesis and metabolism play in HCV-related liver disease risk in males.

Methods

We performed a cross-sectional study evaluating single nucleotide polymorphisms (SNPs) in 16 candidate genes involved in androgen and estrogen ligand and receptor synthesis and risk of advanced hepatic fibrosis (F3/F4-F4) and inflammation (A2/A3-A3). We calculated adjusted odds ratios (ORs) using logistic regression and used multifactor dimensionality reduction (MDR) analysis to assess for gene-environment interaction.

Results

Among 466 chronica

SUBMITTER: White DL 

PROVIDER: S-EPMC4214264 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature