Characterization of osteoblastic and osteolytic proteins in prostate cancer bone metastases.

ABSTRACT:

Background

Approximately 90% of patients who die of Prostate Cancer (PCa) have bone metastases, which promote a spectrum of osteoblastic, osteolytic or mixed bone responses. Numerous secreted proteins have been reported to promote osteoblastic or osteolytic bone responses. We determined whether previously identified and/or novel proteins were associated with the osteoblastic or osteolytic response in clinical specimens of PCa bone metastases.

Methods

Gene expression was analyzed on 14 PCa metastases from 11 patients by microarray profiling and qRT-PCR, and protein expression was analyzed on 33 PCa metastases from 30 patients by immunohistochemistry on highly osteoblastic and highly osteolytic bone specimens.

Results

Transcript and protein levels of BMP-2, BMP-7, DKK-1

SUBMITTER: Larson SR 

PROVIDER: S-EPMC4214278 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature