Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups.

ABSTRACT: Multidrug-resistant and highly virulent Klebsiella pneumoniae isolates are emerging, but the clonal groups (CGs) corresponding to these high-risk strains have remained imprecisely defined. We aimed to identify K. pneumoniae CGs on the basis of genome-wide sequence variation and to provide a simple bioinformatics tool to extract virulence and resistance gene data from genomic data. We sequenced 48 K. pneumoniae isolates, mostly of serotypes K1 and K2, and compared the genomes with 119 publicly available genomes. A total of 694 highly conserved genes were included in a core-genome multilocus sequence typing scheme, and cluster analysis of the data enabled precise definition of globally distributed hypervirulent and multidrug-resistant CGs. In addition, we created a freely accessible database

SUBMITTER: Bialek-Davenet S 

PROVIDER: S-EPMC4214299 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature