Association between FOXP3 promoter polymorphisms and cancer risk: A meta-analysis.

ABSTRACT: Epidemiological studies have been conducted to investigate the association between the FOXP3 promoter polymorphisms, rs3761549 and rs3761548, and the risk of cancer. However, the results from these studies have been controversial. In order to obtain a more precise conclusion of this association, the present meta-analysis was performed. The odds ratio (OR) and 95% confidence interval (95% CI) values were used to assess any correlations between the data. Overall, the rs3761549 (C>T) and rs3761548 (C>A) polymorphisms of the FOXP3 gene were not associated with the cancer risk in an Asian population. In the subgroup analyses based on cancer type, no significant associations were identified between these two polymorphisms and breast cancer. However, the results altered when the analyses were res

SUBMITTER: Jiang LL 

PROVIDER: S-EPMC4214479 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature