A new rhesus macaque assembly and annotation for next-generation sequencing analyses.

ABSTRACT:

Background

The rhesus macaque (Macaca mulatta) is a key species for advancing biomedical research. Like all draft mammalian genomes, the draft rhesus assembly (rheMac2) has gaps, sequencing errors and misassemblies that have prevented automated annotation pipelines from functioning correctly. Another rhesus macaque assembly, CR_1.0, is also available but is substantially more fragmented than rheMac2 with smaller contigs and scaffolds. Annotations for these two assemblies are limited in completeness and accuracy. High quality assembly and annotation files are required for a wide range of studies including expression, genetic and evolutionary analyses.

Results

We report a new de novo assembly of the rhesus macaque genome (MacaM) that incorporates both the original Sanger seque

SUBMITTER: Zimin AV 

PROVIDER: S-EPMC4214606 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature