Co-trimoxazole and sudden death in patients receiving inhibitors of renin-angiotensin system: population based study.

ABSTRACT:

Objective

To determine whether the prescription of co-trimoxazole with an angiotensin converting enzyme inhibitor or angiotensin receptor blocker is associated with sudden death.

Design

Population based nested case-control study.

Setting

Ontario, Canada, from 1 April 1994 to 1 January 2012.

Participants

Ontario residents aged 66 years or older treated with an angiotensin converting enzyme inhibitor or angiotensin receptor blocker. Cases were those who died suddenly shortly after receiving an outpatient prescription for one of co-trimoxazole, amoxicillin, ciprofloxacin, norfloxacin, or nitrofurantoin. Each case was matched with up to four controls on age, sex, chronic kidney disease, and diabetes.

Main outcome measure

Odds ratio for the association betwee

SUBMITTER: Fralick M 

PROVIDER: S-EPMC4214638 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature