Identification and lateral membrane localization of cyclin M3, likely to be involved in renal Mg2+ handling in seawater fish.

ABSTRACT: The kidney of marine teleosts is the major site of Mg(2+) excretion and produces urine with a high Mg(2+) concentration. However, the transporters involved in Mg(2+) excretion are poorly understood. The cyclin M (Cnnm; also known as ancient conserved domain protein) family comprises membrane proteins homologous to the bacterial Mg(2+) and Co(2+) efflux protein, CorC. To understand the molecular mechanism of Mg(2+) homeostasis in marine teleosts, we analyzed the expression of the Cnnm family genes in the seawater (SW) pufferfish, torafugu (Takifugu rubripes), and the closely related euryhaline species, mefugu (Takifugu obscurus). Database mining and phylogenetic analysis indicated that the Takifugu genome contains six members of the Cnnm family: two orthologs of Cnnm1, one of Cnnm2, one of

SUBMITTER: Islam Z 

PROVIDER: S-EPMC4214835 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature