Inhalation of rod-like carbon nanotubes causes unconventional allergic airway inflammation.

ABSTRACT:

Background

Carbon nanotubes (CNT) represent a great promise for technological and industrial development but serious concerns on their health effects have also emerged. Rod-shaped CNT are, in fact, able to induce asbestos-like pathogenicity in mice including granuloma formation in abdominal cavity and sub-pleural fibrosis. Exposure to CNT, especially in the occupational context, happens mainly by inhalation. However, little is known about the possible effects of CNT on pulmonary allergic diseases, such as asthma.

Methods

We exposed mice by inhalation to two types of multi-walled CNT, rigid rod-like and flexible tangled CNT, for four hours a day once or on four consecutive days. Early events were monitored immediately and 24 hours after the single inhalation exposure and the

SUBMITTER: Rydman EM 

PROVIDER: S-EPMC4215016 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature