Ankylosing spondylitis is associated with the anthrax toxin receptor 2 gene (ANTXR2).

ABSTRACT:

Objectives

ANTXR2 variants have been associated with ankylosing spondylitis (AS) in two previous genome-wide association studies (GWAS) (p∼9×10(-8)). However, a genome-wide significant association (p<5×10(-8)) was not observed. We conducted a more comprehensive analysis of ANTXR2 in an independent UK sample to confirm and refine this association.

Methods

A replication study was carried out with 2978 cases and 8365 controls. Then, these were combined with non-overlapping samples from the two previous GWAS in a meta-analysis. Human leukocyte antigen (HLA)-B27 stratification was also performed to test for ANTXR2-HLA-B27 interaction.

Results

Out of nine single nucleotide polymorphisms (SNP) in the study, five SNPs were nominally associated (p<0.05) with AS in the replicat

SUBMITTER: Karaderi T 

PROVIDER: S-EPMC4215346 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature