Cytoreductive prostatectomy: evidence in support of a new surgical paradigm (Review).

ABSTRACT: Prostate cancer (PCa) remains the second ranked cause of cancer deaths in the United States. The current standard of care for metastatic prostate cancer (mPCa) includes systemic therapies with no option for surgery. In contrast, in other malignancies such as breast and kidney cancer, cyto-reduction plays an integral role in the treatment of metastatic disease. In this framework, there are emerging data that suggest a potential oncologic benefit to cytoreduction in mPCa. The majority of the data are retrospective in nature suggesting that patients with mPCa who had prior radical prostatectomy (RP) had a better survival, as well as improved response to systemic therapy. Similarly, patients who presented with metastatic disease and received definitive local therapy (RP or radiation) had great

SUBMITTER: Faiena I 

PROVIDER: S-EPMC4215584 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature