Myelin-specific T helper 17 cells promote adult hippocampal neurogenesis through indirect mechanisms.

ABSTRACT: CD4 ⁺ T cells provide a neuro-immunological link in the regulation of adult hippocampal neurogenesis, but the exact mechanisms underlying enhanced neural precursor cell proliferation and the relative contribution of different T helper (Th) cell subsets have remained unclear. Here, we explored the pro-proliferative potential of interleukin 17-producing T helper (Th17) cells, a developmentally and functionally distinct Th cell subset that is a key mediator of autoimmune neurodegeneration. We found that base-line proliferation of hippocampal precursor cells in a T cell-deficient mouse model of impaired hippocampal neurogenesis can be restored upon adoptive transfer with homogeneous Th17 populations enriched for myelin-reactive T cell receptors (TCR). In these experiments, enhanced

SUBMITTER: Niebling J 

PROVIDER: S-EPMC4215755 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature