Simple, biologically-constrained CA1 pyramidal cell models using an intact, whole hippocampus context.

ABSTRACT: The hippocampus is a heavily studied brain structure due to its involvement in learning and memory. Detailed models of excitatory, pyramidal cells in hippocampus have been developed using a range of experimental data. These models have been used to help us understand, for example, the effects of synaptic integration and voltage gated channel densities and distributions on cellular responses. However, these cellular outputs need to be considered from the perspective of the networks in which they are embedded. Using modeling approaches, if cellular representations are too detailed, it quickly becomes computationally unwieldy to explore large network simulations. Thus, simple models are preferable, but at the same time they need to have a clear, experimental basis so as to allow physiological

SUBMITTER: Ferguson KA 

PROVIDER: S-EPMC4215760 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature