Quantitative leukocyte BDNF promoter methylation analysis in bipolar disorder.

ABSTRACT:

Background

Bipolar disorder (BD) is a complex psychiatric phenotype with a high heritability and a multifactorial etiology. Multisite collaborative efforts using genome-wide association studies (GWAS) have identified only a portion of DNA sequence-based risk factors in BD. In addition to predisposing DNA sequence variants, epigenetic misregulation may play an etiological role in BD and account for monozygotic twin discordance, parental origin effects, and fluctuating course of BD. In this study, we investigated DNA methylation of the brain-derived neurotrophic factor (BDNF) gene in BD.

Methods

Fifty participants with BD were compared to the same number of age- and sex-matched controls for DNA methylation differences at BDNF promoters 3 and 5. DNA methylation reads were obtai

SUBMITTER: Strauss JS 

PROVIDER: S-EPMC4215812 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature