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Fabrication of corona-free nanoparticles with tunable hydrophobicity.

ABSTRACT: A protein corona is formed at the surface of nanoparticles in the presence of biological fluids, masking the surface properties of the particle and complicating the relationship between chemical functionality and biological effects. We present here a series of zwitterionic NPs of variable hydrophobicity that do not adsorb proteins at moderate levels of serum protein and do not form hard coronas at physiological serum concentrations. These particles provide platforms to evaluate nanobiological behavior such as cell uptake and hemolysis dictated directly by chemical motifs at the nanoparticle surface.

SUBMITTER: Moyano DF

PROVIDER: S-EPMC4215884 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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Fabrication of corona-free nanoparticles with tunable hydrophobicity.

Moyano Daniel F DF Saha Krishnendu K Prakash Gyan G Yan Bo B Kong Hao H Yazdani Mahdieh M Rotello Vincent M VM

ACS nano 20140711 7

A protein corona is formed at the surface of nanoparticles in the presence of biological fluids, masking the surface properties of the particle and complicating the relationship between chemical functionality and biological effects. We present here a series of zwitterionic NPs of variable hydrophobicity that do not adsorb proteins at moderate levels of serum protein and do not form hard coronas at physiological serum concentrations. These particles provide platforms to evaluate nanobiological be ...[more]

PMID: 24971670

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