Acceptability and feasibility of repeated mucosal specimen collection in clinical trial participants in Kenya.

ABSTRACT:

Background

Mucosal specimens are essential to evaluate compartmentalized immune responses to HIV vaccine candidates and other mucosally targeted investigational products. We studied the acceptability and feasibility of repeated mucosal sampling in East African clinical trial participants at low risk of HIV and other sexually transmitted infections.

Methods and findings

The Kenya AIDS Vaccine Initiative (KAVI) enrolled participants into three Phase 1 trials of preventive HIV candidate vaccines in 2011-2012 at two clinical research centers in Nairobi. After informed consent to a mucosal sub-study, participants were asked to undergo collection of mucosal secretions (saliva, oral fluids, semen, cervico-vaginal and rectal), but could opt out of any collection at any visit. Specim

SUBMITTER: Omosa-Manyonyi G 

PROVIDER: S-EPMC4215886 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature