Liver stiffness measurement-based scoring system for significant inflammation related to chronic hepatitis B.

ABSTRACT:

Objectives

Liver biopsy is indispensable because liver stiffness measurement alone cannot provide information on intrahepatic inflammation. However, the presence of fibrosis highly correlates with inflammation. We constructed a noninvasive model to determine significant inflammation in chronic hepatitis B patients by using liver stiffness measurement and serum markers.

Methods

The training set included chronic hepatitis B patients (n = 327), and the validation set included 106 patients; liver biopsies were performed, liver histology was scored, and serum markers were investigated. All patients underwent liver stiffness measurement.

Results

An inflammation activity scoring system for significant inflammation was constructed. In the training set, the area under the curv

SUBMITTER: Hong MZ 

PROVIDER: S-EPMC4216134 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature