Assessment of cerebrovascular reactivity during resting state breathing and its correlation with cognitive function in hypertension.

ABSTRACT:

Background

Hypertension is associated with cognitive deficits, particularly executive function, and decreased cerebral microvascular responsiveness to CO2 (CO2 vasoreactivity). The relation between CO2 vasoreactivity and executive function is not known. Protocols to assess CO2 vasoreactivity are cumbersome and require inhaling a CO2-enriched gas. We explored the ability to measure CO2 vasoreactivity using end-tidal CO2 fluctuations during normal breathing and the association of this measure with cognitive function in hypertension.

Methods

Executive function (Trail-Making Test parts A/B), memory, attention and blood flow velocity (BFV) in the middle cerebral artery using transcranial Doppler were measured in hypertensive subjects who were tapered off their treatment for 3 wee

SUBMITTER: Hajjar I 

PROVIDER: S-EPMC4216224 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature