Mechanical modulation of nascent stem cell lineage commitment in tissue engineering scaffolds.

ABSTRACT: Taking inspiration from tissue morphogenesis in utero, this study tests the concept of using tissue engineering scaffolds as delivery devices to modulate emergent structure-function relationships at early stages of tissue genesis. We report on the use of a combined computational fluid dynamics (CFD) modeling, advanced manufacturing methods, and experimental fluid mechanics (micro-piv and strain mapping) for the prospective design of tissue engineering scaffold geometries that deliver spatially resolved mechanical cues to stem cells seeded within. When subjected to a constant magnitude global flow regime, the local scaffold geometry dictates the magnitudes of mechanical stresses and strains experienced by a given cell, and in a spatially resolved fashion, similar to patterning during morpho

SUBMITTER: Song MJ 

PROVIDER: S-EPMC4216563 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature