Prevalence and frequency of circulating t(14;18)-MBR translocation carrying cells in healthy individuals.

ABSTRACT: The t(14;18) translocation is a common genetic aberration that can be seen as an early step in pathogenesis of follicular lymphoma (FL). The significance of low level circulating t(14;18)-positive cells in healthy individuals as clonal lymphoma precursors or indicators of risk is still unclear. We determined the age dependent prevalence and frequency of BCL2/IgH rearrangements in 715 healthy individuals ranging from newborns to octo- and nonagenarians. These results were compared with number of circulating t(14;18)-positive cells in 108 FL patients at initial presentation. The overall prevalence of BCL2/IgH junctions in this large sample was 46% (327/715). However, there was a striking dependence upon age. Specifically, among individuals up to 10 years old, none had detectable circulating

SUBMITTER: Schuler F 

PROVIDER: S-EPMC4216731 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature