Intracellular trafficking of Gag and Env proteins and their interactions modulate pseudotyping of retroviruses.

ABSTRACT: Glycoproteins derived from most retroviruses and from several families of enveloped viruses can form infectious pseudotypes with murine leukemia virus (MLV) and lentiviral core particles, like the MLV envelope glycoproteins (Env) that are incorporated on either virus type. However, coexpression of a given glycoprotein with heterologous core proteins does not always give rise to highly infectious viral particles, and restrictions on pseudotype formation have been reported. To understand the mechanisms that control the recruitment of viral surface glycoproteins on lentiviral and retroviral cores, we exploited the fact that the feline endogenous retrovirus RD114 glycoprotein does not efficiently pseudotype lentiviral cores derived from simian immunodeficiency virus, whereas it is readily inco

SUBMITTER: Sandrin V 

PROVIDER: S-EPMC421692 | biostudies-literature | 2004 Jul

REPOSITORIES: biostudies-literature