Preservation of genetic and regulatory robustness in ancient gene duplicates of Saccharomyces cerevisiae.

ABSTRACT: Biological systems remain robust against certain genetic and environmental challenges. Robustness allows the exploration of ecological adaptations. It is unclear what factors contribute to increasing robustness. Gene duplication has been considered to increase genetic robustness through functional redundancy, accelerating the evolution of novel functions. However, recent findings have questioned the link between duplication and robustness. In particular, it remains elusive whether ancient duplicates still bear potential for innovation through preserved redundancy and robustness. Here we have investigated this question by evolving the yeast Saccharomyces cerevisiae for 2200 generations under conditions allowing the accumulation of deleterious mutations, and we put mechanisms of mutational r

SUBMITTER: Keane OM 

PROVIDER: S-EPMC4216924 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature