CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits.

ABSTRACT:

Background

Genetic understanding of complex traits has developed immensely over the past decade but remains hampered by incomplete descriptions of contribution to phenotypic variance. Gene-environment (GxE) interactions are one of these contributors and in the guise of diet and physical activity are important modulators of cardiometabolic phenotypes and ensuing diseases.

Results

We mined the scientific literature to collect GxE interactions from 386 publications for blood lipids, glycemic traits, obesity anthropometrics, vascular measures, inflammation and metabolic syndrome, and introduce CardioGxE, a gene-environment interaction resource. We then analyzed the genes and SNPs supporting cardiometabolic GxEs in order to demonstrate utility of GxE SNPs and to discern character

SUBMITTER: Parnell LD 

PROVIDER: S-EPMC4217104 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature