Regulation of Pseudomonas aeruginosa virulence factors by two novel RNA thermometers.

ABSTRACT: In a number of bacterial pathogens, the production of virulence factors is induced at 37 °C; this effect is often regulated by mRNA structures formed in the 5' untranslated region (UTR) that block translation initiation of genes at environmental temperatures. At 37 °C, the RNA structures become unstable and ribosomes gain access to their binding sites in the mRNAs. Pseudomonas aeruginosa is an important opportunistic pathogen and the expression of many of its virulence-associated traits is regulated by the quorum-sensing (QS) response, but the effect of temperature on virulence-factor expression is not well-understood. The aim of this work is the characterization of the molecular mechanism involved in thermoregulation of QS-dependent virulence-factor production. We demonstrate that traits

SUBMITTER: Grosso-Becerra MV 

PROVIDER: S-EPMC4217398 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature