Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance.

ABSTRACT: Lipid accumulation in obesity triggers a low-grade inflammation that results from an imbalance between pro- and anti-inflammatory components of the immune system and acts as the major underlying mechanism for the development of obesity-associated diseases, notably insulin resistance and type 2 diabetes. Innate-like B cells are a subgroup of B cells that respond to innate signals and modulate inflammatory responses through production of immunomodulatory mediators such as the anti-inflammatory cytokine IL-10. In this study, we examined innate-like B cells in visceral white adipose tissue (VAT) and the relationship of these cells with their counterparts in the peritoneal cavity and spleen during diet-induced obesity (DIO) in mice. We show that a considerable number of innate-like B cells bear

SUBMITTER: Wu L 

PROVIDER: S-EPMC4217427 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature