Nocebo effect in randomized clinical trials of antidepressants in children and adolescents: systematic review and meta-analysis.

ABSTRACT:

Objective

To compare the incidence of adverse events between active and placebo arms of randomized clinical trials in depressive children and adolescents (C&A) with antidepressant treatments, in order to look for similarities in both groups that allow to establish a possible nocebo effect.

Methods

Systematic search strategy (January 1974-March 2013) in electronic databases, conference abstracts, and reference list of systematic reviews and included studies to identify parallel randomized placebo-controlled trials of antidepressants in C&A (<19 years) with major depressive disorder, and one or more interventions of any orally administered antidepressant. The pooled adverse events were calculated based on a fixed-effect model and statistical analysis involved the risk ratio (R

SUBMITTER: Rojas-Mirquez JC 

PROVIDER: S-EPMC4217505 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature