Prevalence of Quinolone Resistance Among Extended-Spectrum β -Lactamase Producing Uropathogenic Klebsiella pneumoniae.

ABSTRACT:

Background

Extended-spectrum β-lactamase (ESBL) production is the major resistance mechanism to β-lactam antibiotics in Enterobacteriaceae. In addition, emergence of plasmid-mediated quinolone resistance (PMQR) in ESBL-producing isolates has become a global threat for treatment of these infections.

Objectives

We investigated the association between ESBL production and quinolone resistance in urinary isolates of K. pneumoniae.

Patients and methods

A total of 196 urinary isolates of K. pneumoniae were collected from Imam Hussein Hospital in Tehran during a four year period (2008-2012). Antibiotic susceptibility was determined by disc diffusion and ESBL production was screened using the phenotypic confirmatory test (PCT).

Results

All isolates were susceptible to i

SUBMITTER: Raei F 

PROVIDER: S-EPMC4217673 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature