Evidence for deep regulatory similarities in early developmental programs across highly diverged insects.

ABSTRACT: Many genes familiar from Drosophila development, such as the so-called gap, pair-rule, and segment polarity genes, play important roles in the development of other insects and in many cases appear to be deployed in a similar fashion, despite the fact that Drosophila-like "long germband" development is highly derived and confined to a subset of insect families. Whether or not these similarities extend to the regulatory level is unknown. Identification of regulatory regions beyond the well-studied Drosophila has been challenging as even within the Diptera (flies, including mosquitoes) regulatory sequences have diverged past the point of recognition by standard alignment methods. Here, we demonstrate that methods we previously developed for computational cis-regulatory module (CRM) discovery

SUBMITTER: Kazemian M 

PROVIDER: S-EPMC4217690 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature