IT-11A PHASE I/ II CLINICAL TRIAL OF CT-011 (PIDILIZUMAB) IN DIFFUSE INTRINSIC PONTINE GLIOMA AND RELAPSED HIGH GRADE GLIOMA: A PRELIMINARY REPORT

ABSTRACT: BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) and relapsed high grade glioma (HGG) are incurable diseases with an event free survival of 6-8 months. Anti-Programmed Death 1 (anti-PD1) antibodies have recently emerged as a promising treatment modality in multiple cancer types. Clinical studies evaluating anti PD1 antibodies in the setting of primary brain tumors have not yet been reported. Pidilizumab (CureTech, Yavne, Israel) is an anti- PD1 humanized immunoglubulin G1 monoclonal antibody. This investigator-initiated clinical trial evaluates pidilizumab in malignant gliomas (NCT01952769). METHODS: Patients older than 3 years treated with not more than 2mg/M2 of dexamethasone per day are included. Patients with newly diagnosed DIPG are recruited for biweekly pidilizumab within the fir

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PROVIDER: S-EPMC4218260 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature